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Exclusion Zone (EZ) water- battery
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Mitochondrial dysfunction and disease
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Mitochondria and cell nucleus communication
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Oxidation and Reduction agents (REDOX)
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Pattern recognition receptors (PRR)
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Damage associated molecular patterns (DAMPS)
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Pattern associated molecular patterns (PAMPS)
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Bacterial antigen binding to mitochondrial receptors
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Cross mitochondria communication
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Mitochondria - ancient archaea
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Mitochondria - immune system alert and activation
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What are reactive oxygen species (ROS) free radicals?
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What is REDOX?
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ROS signalling molecules
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What is apoptosis?
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What is necrosis?
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The mitochondrial engines ATP synthase
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Protein gradient and spin to produce ATP
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Aerobic respiration vs fatty acids
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Electron chain transport
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Electron leakage and free radical production
-
Where is the highest concentration of mitochondria in the
body?
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The gut mitochondria connection
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The Gut- last line of defence in the body
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Mitochondria and gut microbiome interaction
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PGC1 alpha, AMPK, SIRTUINS
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What happens locally impacts the body systemically
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Why do we see disease manifested in the gut first?
-
Microbiome imbalance and inflammatory cascade
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Gut- absorption system first and barrier second
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Leaky gut, the tipping point
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Immune system- Hurt or Heal
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Tight junction proteins
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Microbiota development for optimal host symbiosis
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Creating a harmonious environment for your microbiota and
mitochondria
-
Gut Unicorns
-
How do mitochondria and microbiota communicate
bidirectionally
-
Microbiota metabolites for mitochondrial fuel
-
Short-chain fatty acids
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Urolithins- Mitochondrial biogenesis
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Up-regulation of transcription factors PGC1 alpha, AMPK,
SIRTUINS and fat metabolism
-
Mitochondria and gut barrier function
-
Redox status of the cell, gut barrier, microbiota and
mitochondrial function
-
Metabolites Hydrogen sulphide, nitric oxide and mitochondrial
energy production
-
Butyrate production - fuel for enterocytes
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A new gut lining every 3 to 5 days
-
Drug targeting and microbiota
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Molecular mimicry and autoimmune disease
-
How do we improve mitochondrial function?
-
Metabolic flexibility
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Time-Restricted Eating
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Cofactor for Mitochondrial Health
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Micronutrient Dense Diet
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Walking, High Intensity and Resistance Training
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Optimising your Digestive System
-
Food Choices for optimal gut health
-
Variety of Plant foods for Microbiota diversity
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What is Hormesis?
-
Intermittent Fasting
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Cold Exposure and Sauna
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Antioxidants, polyphenols and microbiota diversity
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Autophagy vs Mitophagy vs Mitochondrial biogenesis
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Clinical examples- Weight loss
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Clinical examples- Gut health
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Evolutionary Biology
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Roland’s top tip for Gut Health